New New Cyclone Balance Black Balance Women's vaw5wRqU New New Cyclone Balance Black Balance Women's vaw5wRqU New New Cyclone Balance Black Balance Women's vaw5wRqU New New Cyclone Balance Black Balance Women's vaw5wRqU New New Cyclone Balance Black Balance Women's vaw5wRqU New New Cyclone Balance Black Balance Women's vaw5wRqU

New New Cyclone Balance Black Balance Women's vaw5wRqU

Campbell, E. et al. (2014) Malformation risks of antiepileptic drug monotherapies in pregnancy: updated results from the UK and Ireland epilepsy and pregnancy registers. Journal of Neurology, Neurosurgery and Psychiatry, 85(9), pp. 1029-1034. (doi:Vikky puma White Puma Women's Sneaker PUMA Black Fashion Platform fppRqP) (PMID:24444855)

Full text not currently available from Enlighten.

Abstract

Objectives Antiepileptic drug (AED) exposure during pregnancy increases the risk of major congenital malformations (MCMs). The magnitude of this risk varies by AED exposure. Here we provide updated results from the UK Epilepsy and Pregnancy Register of the risk of MCMs after monotherapy exposure to valproate, carbamazepine and lamotrigine.

Methods Fifteen-year prospective observational study from 1996 until 2012. The main outcome measure is the MCM rate.

Results Informative outcomes were available for 5206 cases. 1290 women were exposed to valproate monotherapy, 1718 to carbamazepine monotherapy and 2198 to lamotrigine monotherapy. The MCM risk with valproate monotherapy exposure in utero was 6.7% (95% CI 5.5% to 8.3%) compared with 2.6% with carbamazepine (95% CI 1.9% to 3.5%) and 2.3% with lamotrigine (95% CI 1.8% to 3.1%). A significant dose effect was seen with valproate (p=0.0006) and carbamazepine (p=0.03) exposed pregnancies. A non-significant trend towards higher MCM rate with increasing dose was found with lamotrigine. MCM rate for high-dose lamotrigine (<400 mg daily) was lower than the MCM rate for pregnancies exposed to <600 mg daily of valproate, but this was not significant (3.4% vs 5.0%, p=0.31).

Conclusions In utero exposure to valproate carries a significantly higher MCM risk than lamotrigine (p=0.0001) and carbamazepine (p=0.0001) monotherapy. In contrast to prior findings, high-dose lamotrigine was associated with fewer MCMs than all doses of valproate. While lamotrigine has a favourable profile compared with valproate for adverse pregnancy outcomes, the requirements for seizure control should not be overlooked.

Floral Dansko Women's Pewter Professional Clog qIzU8Ifw
Item Type: New Women's New Cyclone Black Balance Balance Articles
Status: Published
Refereed: Cyclone Black New New Women's Balance Balance Yes
Glasgow Author(s) Enlighten ID: Russell, Dr Aline
Authors: Campbell, E., Kennedy, F., Russell, A., Smithson, W.H., Parsons, L., Morrison, P. ., Liggan, B., Irwin, B., Delanty, N., Hunt, S.J., Craig, J., and Morrow, J.
Cyclone New Balance Women's Balance New Black College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name: Journal of Neurology, Neurosurgery and Psychiatry
Publisher: BMJ Publishing Group
ISSN: 0022-3050
ISSN (Online): 1468-330X

University Staff: Request a correction | Enlighten Editors: Update this record

Balance Cyclone Women's New New Black Balance 21
1
3

61
0
0
View details on Altmetric's website
Cyclone New Women's Balance New Black Balance Shoe Rawlings Baseball Clubhouse Black Silver Kids' qwt71wY

Balance Women's New Cyclone Balance New Black

  • Women's Balance Cyclone Black New Balance New
Enlighten: Publications uses cookies to store user data when you log in. It also uses Google Analytics to help improve the service offered.

To find out more please visit our cookies information page.
Accept
By clicking accept and continuing to use this site, you agree to allow the use of cookies.